Biosynthesis of Lovastatin by Gamma Irradiated Aspergillus terreus
نویسندگان
چکیده
منابع مشابه
Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium.
Lovastatin is a secondary metabolite produced by Aspergillus terreus. A chemically defined medium was developed in order to investigate the influence of carbon and nitrogen sources on lovastatin biosynthesis. Among several organic and inorganic defined nitrogen sources metabolized by A. terreus, glutamate and histidine gave the highest lovastatin biosynthesis level. For cultures on glucose and ...
متن کاملKinetic Modelling of Lovastatin Biosynthesis by Aspergillus Terreus Cultivated on Lactose and Glycerol as Carbon Sources
A kinetic model to describe lovastatin biosynthesis by Aspergillus terreus ATCC 20542 in a batch culture with the simultaneous use of lactose and glycerol as carbon sources was developed. In order to do this the kinetics of the process was first studied. Then, the model consisting of five ordinary differential equations to balance lactose, glycerol, organic nitrogen, lovastatin and biomass was ...
متن کاملInfluence of oxygen on lovastatin biosynthesis by Aspergillus terreus ATCC 20542 quantitatively studied on the level of individual pellets
Despite oxygen is believed to be the most important environmental factor for any aerobic microbial process, the quantitative studies of its influence on growth and metabolite formation on the level of individual pellets formed by filamentous fungi were seldom performed. Never was it made for lovastatin producer Aspergillus terreus ATCC20542. Thus, this work is a quantitative study of oxygen tra...
متن کاملFermentation optimization for the production of lovastatin by Aspergillus terreus: use of response surface methodology
A Box–Behnken experimental design was used to investigate the effects of five factors—ie oxygen content in the gas phase; concentrations of C, N and P; and fermentation time—on the concentrations of biomass and lovastatin produced in batch cultures of Aspergillus terreus. The values of the various factors in the experiment ranged widely, as follows: 20–80% (v/v) oxygen in the aeration gas; 8–48...
متن کاملProduction of lovastatin and itaconic acid by Aspergillus terreus: a comparative perspective
Aspergillus terreus is a textbook example of an industrially relevant filamentous fungus. It is used for the biotechnological production of two valuable metabolites, namely itaconic acid and lovastatin. Itaconic acid serves as a precursor in polymer industry, whereas lovastatin found its place in the pharmaceutical market as a cholesterol-lowering statin drug and a precursor for semisynthetic s...
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ژورنال
عنوان ژورنال: Journal of Nuclear Technology in Applied Science
سال: 2021
ISSN: 2314-8217
DOI: 10.21608/jntas.2021.54136.1031